Premarin Tablets (0.3mg, 0.625mg, & 1.25mg)
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Premarin is a Hormone Replacement Therapy (HRT). It contains a conjugation of the female hormone oestrogen and is used to treat some of the symptoms and conditions associated with the menopause including osteoporosis.
- Once daily dosage
- Used for women going through menopause
- UK Registered Service
What Is Premarin?
Premarin is a hormone replacement therapy (HRT) that is used to treat the symptoms of menopause; the stage of significant hormonal changes in the female body, as hormone levels drop and the menstrual cycle ends. It contains active ingredients of conjugated oestrogens, which are a substitute for oestrogen, the major female sex hormone. These ingredients include estrone, equilin, 17a-estradiol and 17b-estradiol.
You may be prescribed Premarin in 0.3 mg, 0.625 mg or 1.25 mg strengths, with your dose being adjusted according to factors such as the severity of symptoms and risk of side effects.
What Is Premarin Used For?
Premarin tablets are used to relieve menopause symptoms such as night sweats, hot flushes and vaginal dryness. HRT treatments such as Premarin work by supplementing your hormone levels, which have fallen during menopause. The conjugated oestrogens in Premarin not only replace lost oestrogen and treat menopause symptoms, but they can also help to prevent postmenopausal osteoporosis.
If your womb hasn’t been removed, you will require a treatment containing progesterone to take with your Premarin. This is to ensure that the lining of your womb (endometrium) doesn’t grow excessively, as this reduces the risk of endometrial cancer and other complications.
Premarin and Smoking
You shouldn’t smoke or use tobacco products whilst taking Premarin tablets. Smoking while taking Premarin can increase the risk of serious side effects including serious cardiovascular events, such as:
- Blood clots
- Deep vein thrombosis
- Pulmonary embolism
- Heart attack
If you experience any side effects related to these conditions – such as:
- Pain or an uncomfortable pressure in your chest
- Pain or discomfort in your back, arms, jaw, neck or stomach
- Shortness of breath
It is imperative that you seek medical attention or call 999 as soon as possible.
Premarin and Grapefruit
Grapefruit juice and foods containing grapefruit can increase the side effects of oestrogen – including breast pain or tenderness, nausea, fluid retention and headache - in some women. As the clinical significance of this interaction is unknown, you don’t need to limit your grapefruit consumption, but if you do notice any unusual side effects, report them to your doctor.
Cenestin vs Premarin
Like Premarin, Cenestin is an HRT treatment that is used to treat menopausal symptoms, as well as atrophic vaginitis. Unlike Premarin, Cenestin is not taken to prevent osteoporosis or treat primary ovarian failure. Although the two treatments both contain conjugated oestrogens, they include different active ingredients. Cenestin contains a combination of nine active ingredients – like Premarin, it contains equilin, 17a-estradiol and 17b-estradiol, and other active ingredients including 17a-dihydroequilin, 17b-dihydroequilin, 17a-dihydroequilin, 17b-dihydroequilenin and equilenin.
Cenestin tablets and Premarin tablets are both taken once per day, and come in 0.625 mg and 1.25 mg strengths. While Cenestin is also prescribed in 0.45 mg and 0.9 mg strength tablets, Premarin is also available in a 0.3 mg strength. Cenestin and Premarin share many of the same potential side effects, including nausea, vomiting, stomach pain, bloating, breast tenderness, breast pain, weight changes and headache.
Prempro vs Premarin
Prempro and Premarin are both HRT treatments, but along with the conjugated oestrogens (the active ingredients of Premarin) Prempro also contains medroxyprogesterone, a type of progestin (the female sex hormone) that protects the uterus (womb) from damage, helping to prevent uterine cancer. Prempro and Premarin can both also be used to prevent osteoporosis.
If your uterus is intact, you may be given a combined HRT treatment such as Prempro to replace the oestrogen you have lost during menopause, reducing symptoms such as hot flushes, night sweats and vaginal dryness. The medroxyprogesterone contained in the tablets can help to prevent the thickening of your uterus lining (endometrial hyperplasia) that can be caused by taking conjugated oestrogens.
Prempro comes in a wider range of strengths than Premarin, including: a cream tablet containing 0.3 mg conjugated oestrogens and 1.5 mg medroxyprogesterone, a gold tablet containing 0.45 mg conjugated oestrogens and 1.5 mg medroxyprogesterone, a peach tablet containing 0.625 mg conjugated oestrogens and 2.5 mg medroxyprogesterone, and a light blue tablet containing 0.625 mg conjugated oestrogens and 5 mg medroxyprogesterone. Prempro and Premarin are both taken once per day.
Some users have reported that Premarin was successful in reducing menopausal symptoms such as hot flushes, night sweats, mood swings and loss of libido (sex drive) in a matter of days or weeks. Reviewers online have expressed their happiness that Premarin helped them regain their interest in sex and get their sex life back. However, some users who stopped Premarin reported that their symptoms returned and that they had trouble sleeping.
Can I Buy Premarin Over the Counter?
You can’t purchase Premarin tablets over the counter in the UK. A doctor will need to assess your suitability for the treatment before you can be issued a prescription. Once your suitability has been confirmed, you can use your prescription to purchase Premarin tablets from your local or online pharmacy.
Premarin tablets can be bought online at Cloud Pharmacy. After completing a quick consultation with an online pharmacist, we can then issue you an electronic prescription. Once your prescription has been issued, we can dispense the tablets and send them to you in a discreet package with our next day delivery service.
Premarin tablets come in 0.3 mg, 0.625 mg or 1.25 mg doses. The usual starting dose of Premarin for a woman without a uterus is 0.3 per day. For the treatment of menopausal symptoms, you will be prescribed the lowest effective dose for the shortest time. If a 0.3 mg daily dose has been proven ineffective in treating your symptoms, you may be prescribed a higher dose of Premarin.
How Long Does It Take for Premarin to Work?
The time it takes for women to experience an improvement in menopausal symptoms after starting to take Premarin tablets can vary. You may feel your menopausal symptoms subsiding in as soon as four weeks, with a reduction in the frequency of hot flushes and night sweats.
Your doctor will re-evaluate your prescription periodically to determine if treatment is still necessary. You should take Premarin tablets as prescribed by your doctor, without stopping unless advised to do so. Stopping HRT treatment in the middle of your cycle may cause your hormone levels to drop dramatically, which could lead to menopause symptoms returning.
How to Take Premarin
You should take Premarin at the same time every day if possible. The tablets are swallowed whole with water and can be taken with or without food.
If you forget to take a Premarin dose, take the tablet as soon as you remember, as long as it’s within 12 hours of when you were meant to take the tablet. If 12 hours have passed since you were supposed to take the tablet, simply take your next tablet at the normal time the following day. Never take a double dose to compensate for the dose you missed.
Premarin Side Effects
Although not everyone will experience side effects from Premarin tablets, among the most common potential side effects are:
- Upset stomach
- Breast tenderness
- Breast pain
- Weight changes
If you are concerned about any of these side effects, or they persist, speak to your doctor. More serious potential side effects from Premarin are less common. If you experience any serious side effects such as:
- Unusual vaginal bleeding
- Vaginal irritation
- Vaginal discharge
- Mood swings
- Breast lumps
- Severe stomach pain
- Swollen hands, feet or ankles
Tell your doctor or pharmacist straight away.
Serious problems from Premarin are rare. Contact a medical professional or call 999 immediately if you experience signs of a stroke, heart attack, pulmonary embolism or deep vein thrombosis, such as:
- Profuse sweating
- Chest, arm or jaw pain
- Weakness on one side of the body
- Severe and sudden headache
- Visions changes
- Swelling of the legs
- Breathing difficulty
- Tingling or numbness in the arms or legs
- Dizziness or fainting
- Coughing up blood
Patient Information Leaflet
Premarin Tablets Patient Information Leaflet
For more information on Premarin tablets, take a look at the patient information leaflet below:
Confirm Premarin Tablets (0.3mg, 0.625mg, & 1.25mg) treatment selection