Kliofem Tablets

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Fastest delivery available: 31/05/2024

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Pricing and quantity options

Evorel Patches (25, 50, 75, 100mcg)

Quantities 25mcg
8 Patches £14.89
16 Patches £27.99
24 Patches £34.99
Quantities 50mcg
8 Patches £14.99
16 Patches £27.99
24 Patches £34.99
Quantities 75mcg
8 Patches £14.99
16 Patches £27.99
24 Patches £34.99
Quantities 100mcg
8 Patches £14.99
16 Patches £27.99
24 Patches £34.99

Evorel Conti Patches

8 Patches £24.99
16 Patches £46.99
24 Patches £69.99

Elleste Solo Tablets

Quantities 1mg
84 Tablets £24.99
Quantities 2mg
84 Tablets £26.99

Elleste Duet Tablets (1mg, 2mg & Conti)

Quantities 1mg
84 Tablets £29.99
Quantities 2mg
Quantities Conti
84 Tablets £38.99

Premarin Tablets (0.3mg, 0.625mg, & 1.25mg)

Quantities 0.3mg
84 Tablets £23.99
Quantities 0.625mg
84 Tablets £23.99
Quantities 1.25mg
84 Tablets £23.99

Kliofem Tablets

Quantities 2 mg/ 1 mg
84 Tablets £25.99
168 Tablets £51.99
Qty84 Tablets168 Tablets
Registered UK Pharmacy number 9012073
Please note: This page is only to be used as a reference of our price for this medication. If you are approved you will be offered treatment for you and the prescriber to jointly consider. However, the final decision will always be the prescriber's.

Medication features

Kliofem is a Hormone Replacement Therapy (HRT) suitable for postmenopausal women. Taking Kliofem can support women to find some relief from symptoms of menopause and help prevent osteoporosis.

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  • Treats menopausal symptoms
  • Oestrogen & Norethisterone
  • UK Registered Service

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What Is Kliofem?

Kliofem is a hormone replacement therapy (HRT) that is prescribed to ease the symptoms of menopause – this is the stage when female hormone levels decrease and major hormonal changes occur in the female body. The medication is available in 1 mg and 2 mg tablets.

This combined HRT treatment contains two active ingredients; these are estradiol (a form of the major female sex hormone oestrogen), and norethisterone (a synthetic form of progesterone, the hormone which is important for menstruation and pregnancy).

Combined HRT treatments such as Kliofem are suitable for women who still have a womb and require norethisterone as well as an oestrogen replacement.

What Is Kliofem Used For?

If taking an oestrogen-only HRT treatment risks causing the thickening of your womb, you may be prescribed Kliofem. By adding a progesterone hormone such as norethisterone to the oestrogen, Kliofem can help to shed the lining of your womb and prevent problems that may arise from endometrial hyperplasia (the thickening of the womb lining), such as heavy menstrual periods and postmenopausal bleeding.

The estradiol in Kliofem tablets can supplement oestrogen levels in the body, compensating for the drop in levels of the hormone during menopause. Estradiol can relieve symptoms like:

  • Night sweats
  • Hot flushes
  • Vaginal itching and dryness
  • Mood swings

Norethisterone, the synthetic form of progesterone, helps to shed the womb’s lining, reducing the risk of build-up in the womb lining caused by taking an oestrogen-only HRT.

Kliofem and Bleeding

During the first 3-6 months of taking Kliofem, you may experience irregular bleeding or spotting. This light vaginal bleeding is nothing to be worried about and may be the result of the increased hormone levels caused by the treatment.

However, if the irregular bleeding persists for more than the first 6 months, begins after you have been taking Kliofem for more than 6 months, or continues after you have stopped taking Kliofem - speak to your doctor as soon as possible.

Kliofem and Alcohol

Kliofem does not typically cause side effects when drinking alcohol, so is generally considered safe. However, some studies suggest there is a link between an increased risk of breast cancer and drinking alcohol while taking an HRT treatment. As more research is required in this area, it is sensible to limit your alcohol while taking an HRT treatment such as Kliofem.

Is Kliofem the Same as Elleste Duet?

Kliofem and Elleste Duet are both combined HRT treatments containing the same active ingredients. If you are a woman with an intact womb, you may be prescribed either Kliofem or Elleste Duet to relieve menopause symptoms such as night sweats and hot flushes. The two treatments both contain estradiol and norethisterone.

A significant difference between Kliofem and Elleste Duet is the form of the tablets. Kliofem is a combined tablet containing 2 mg of estradiol and 1 mg of norethisterone. However, Elleste Duet comes in packs containing separate estradiol and norethisterone tablets. There are three variations of Elleste Duet packs – a 1 mg pack, a 2 mg pack, and an Elleste Duet Conti pack containing 2 mg estradiol and 1 mg norethisterone; the same strengths as Kliofem.

Kliofem vs Kliovance

Kliofem and Kliovance are both combined HRT treatments and contain the same active ingredients - estradiol (a type of oestrogen, the major female sex hormone), and norethisterone (a synthetic type of the progesterone hormone which plays an important part in menstruation and pregnancy). They both come in tablet form and are used to treat menopausal symptoms such as night sweats, hot flushes, vaginal dryness and insomnia. Kliofem and Kliovance share some of the same potential side effects, including:

  • Headache
  • Nausea
  • Breast pain
  • Breast tenderness
  • Breast inflammation
  • Depression

The significant difference between Kliofem and Kliovance is their strength. Kliovance contains half the amount of active ingredients as Kliofem – that is 1 mg of estradiol and 0.5 mg of norethisterone. As Kliofem is stronger than Kliovance, your doctor may prescribe Kliofem if Kliovance has not been effective in reducing your menopausal symptoms.

Kliofem Reviews

Users have highlighted Kliofem’s effectiveness in reducing their menopausal symptoms like night sweats, hot flushes and mood swings. Some online reviewers have reported that Kliofem started to work in just a few days or weeks, while others said it was several weeks before they began to feel relief from their symptoms. Users have commented that Kliofem tablets made them feel less tired.

Side effects of Kliofem commonly cited by users online include spotting and stomach cramps. Some reviewers observed that after they ceased taking Kliofem due to side effects, their menopausal symptoms returned.

Can I Buy Kliofem Over the Counter?

Kliofem tablets aren’t available to buy over the counter in the UK. Your suitability for this HRT treatment will need to be confirmed by a doctor before you are permitted to purchase it. After your suitability has been confirmed and you have a prescription, you can purchase Kliofem from online, high street and supermarket pharmacies.

You can buy Kliofem using Cloud Pharmacy’s online service. After completing a quick consultation, one of our online pharmacists can approve your request and dispense your medication. We will then dispatch your Kliofem tablets in a discreet package via our next-day delivery service.

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Kliofem Dosage

Kliofem tablets have one dosage. The dosage amount for an adult is one tablet per day. Each tablet contains a combination of 2 mg estradiol and 1 mg norethisterone.

How Long Does It Take for Kliofem to Work?

You can expect to begin feeling the benefits of taking Kliofem within ten days. However, it could take up to three months until you feel the full effect of the treatment. You will typically use Kliofem for at least three months so that your doctor can assess its effectiveness.

Continue taking Kliofem tablets until you are advised to stop the treatment by your doctor. Never stop an HRT treatment before your treatment cycle is finished, as this might result in a sudden drop in hormone levels that causes your menopause symptoms to return.

How to Take Kliofem

Always follow the instructions provided with your medication. Take Kliofem tablets at the same time each day, with or without food. Swallow the tablets whole with a glass of water. Never crush, chew or break the tablets. After you have finished a pack of 28 tablets, move on to the next pack of tablets immediately. If you begin taking Kliofem after another HRT treatment, you will be given instructions by your doctor on when to stop your previous treatment and begin taking Kliofem.

If you forget to take a dose of Kliofem, take the tablet as soon as you remember. When 12 hours have passed since it should have been taken, skip the missed dose and take the next tablet when you normally would, the following day. Don’t take two tablets in order to make up for the missed dose. If you do miss a tablet, you may be more likely to have vaginal bleeding.

Side Effects
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Kliofem Side Effects

The most common potential side effects of Kliofem, which can affect more than one in ten people, include:

  • Vaginal bleeding
  • Breast pain or tenderness

Other common potential side effects, which may affect up to one in ten people, include:

  • Weight gain
  • Headache
  • Migraine
  • Vaginal inflammation
  • Vaginal infection
  • Stomach pain
  • Discomfort
  • Breast inflammation
  • Swelling of the limbs (peripheral oedema)
  • Leg cramps
  • Back pain
  • Nausea
  • Depression
  • Benign tumour (uterine fibroid)

Uncommon side effects, which may be experienced by up to one in 100 people, include:

  • Abnormal hair growth
  • Hair loss
  • Acne
  • Bloating
  • Flatulence
  • Vein inflammation
  • Itching
  • Anxiety
  • Allergic reaction

Severe side effects from Kliofem are rare. Blood clots in the legs or lungs may affect up to one in 1,000 people. Even rarer severe side effects, which may affect up to one in 10,000 people, include:

  • Excessive growth of the womb’s lining
    Endometrial cancer (cancer of the womb lining)
  • Gallbladder disease
  • Increased blood pressure
  • Vomiting
  • Oedema attack (fluid build-up in the body)
  • Sebum secretion (an eruption of the oily, waxy substance through the skin)
  • Reduced libido (a loss of interest in sex)
  • Insomnia
  • Weight loss
  • Heartburn
  • Changes to sight
  • Stroke
  • Heart attack

If you experience any of the above, please contact a medical professional or call 999 if you are experiencing symptoms of a stroke or heart attack.

Patient Information Leaflet
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Kliofem Tablets Patient Information Leaflet

For more information on Kliofem medication, take a look at the patient Information Leaflet below:

Kliofem Tablets Reviews

Confirm Kliofem Tablets treatment selection

2 mg/ 1 mg 84 Tablets £25.99
2 mg/ 1 mg 168 Tablets £51.99