• esomeprazole online

Images for illustration purposes only. Brands may vary.


In Stock

Fastest delivery available: 16/07/2024

For more information on our delivery times, please click here

Order it within: 24 hours

Pricing and quantity options

Losec MUPS Tablets

Quantities 10mg
28 £27.99
Quantities 20mg
28 £27.99


Quantities 10mg
28 £8.49
56 £15.99
Quantities 20mg
28 £12.99
56 £19.99


Quantities 10mg
28 £19.99
Quantities 20mg
28 £29.99
56 £44.99


Quantities 20mg
14 Tablets £14.99
28 Tablets £17.99
28 Capsules £17.99
28 Capsules £19.99
56 Tablets £23.99
56 Capsules £23.99
Quantities 40mg
14 Tablets £15.99
28 Tablets £19.99
56 Tablets £24.99
56 Capsules £24.99


Quantities 15mg
14 Capsules £11.89
28 Capsules £15.99
28 Orodispersible £24.89
Quantities 30mg
14 Capsules £12.89
28 Capsules £17.89
28 Orodispersible £26.89


Quantities 20mg
28 £33.99


Quantities 20mg
14 £14.99
28 £19.99
Quantities 40mg
14 £15.99
28 £21.99

Famotidine Tablets

Quantities 20mg
28 £31.99
56 £60.98
84 £91.47
Qty28 Capsules56 Capsules28 Capsules14 Tablets28 Tablets56 Tablets
Qty56 Capsules14 Tablets28 Tablets56 Tablets
Registered UK Pharmacy number 9012073
Please note: This page is only to be used as a reference of our price for this medication. If you are approved you will be offered treatment for you and the prescriber to jointly consider. However, the final decision will always be the prescriber's.

Medication features

Esomeprazole is an effective and safe treatment for acid reflux, indigestion, and heartburn. It helps relieve symptoms for up to 24 hours that have been caused by excess acid produced by the stomach. Symptoms may include stomach bloating, chest pain, and discomfort. Your doctor or pharmacist will determine the most effective strength and dosage for your needs.

View product details
  • Effective acid reflux and heartburn medication
  • Provides up to 24 hours of relief 
  • 20mg & 40mg strengths available 
  • Free online consultation 
  • Next-day delivery 

Esomeprazole Summary

Medicine TypeProton pump inhibitor (PPI)
Mechanism of ActionReduces the amount of acid produced by the stomach.
Active Ingredientesomeprazole
Effective Within2-3 days
Pack Size14-56 tablets
Strength20mg and 40mg 

Learn moreicon-arrow-right

What is Esomeprazole and How Does it Work?

Esomeprazole is a medication that is used to treat the symptoms of acid reflux, heartburn, indigestion, and other stomach and oesophagus problems. It works by decreasing the amount of acid that your stomach is producing, relieving symptoms caused by excess stomach acid.

You can buy Esomeprazole 20mg or 40mg from Cloud Pharmacy after completing a quick online assessment to determine if this medicine is suitable for you. Once completed, your medication can be dispensed to you.

Suitable for ages: 12 years +

Maximum per order:

  • 20mg Esomeprazole: 28-56 tablets
  • 40mg Esomeprazole: 28-56 tablets

Consultation required: Yes

How Long Does Esomeprazole Last For?

After taking a dose of Esomeprazole, its effects can last longer than 24 hours.

Can You Buy Esomeprazole Over the Counter?

No. Esomeprazole is only available for purchase in the UK with a prescription. You can fill out a free online assessment before a quick online consultation with a registered Cloud Pharmacy pharmacist.

Esomeprazole Medication Alternatives

As we are all different, not all medications can be suitable suitable for everyone. Therefore, it is important to know about alternative options available to treat symptoms caused by acid reflux and heartburn. During your free online consultation with a Cloud Pharmacy pharmacist, they may recommend:

  • Losec MUPs Tablets: Losec contains the active ingredient Omeprazole. These tablets are available as multi-unit pellet systems (MUPs)
  • Losec: The brand name of Omeprazole, effective at reducing the production of stomach acid
  • Omeprazole: is available in 10mg and 20mg tablets and is used to help reduce the amount of stomach acid you produce
  • Lansoprazole: A proton pump inhibitor (PPI) that works to treat indigestion, heartburn, and other conditions that are caused by excess stomach acid production
  • Nexium: Nexium is the brand name of Esomeprazole, and it works to reduce the amount of stomach acid you produce
  • Pantoprazole: Belongs to a class of drugs called proton pump inhibitors (PPI) and works by preventing specific cells in the stomach lining from making too much acid
  • Famotidine: Contains the active ingredient famotidine, which, when taken, works to relieve symptoms of acid reflux and heartburn

Esomeprazole Over the Counter Alternatives

Over-the-counter alternatives to Esomeprazole in the UK include:

  • Pepto-Bismol: Another popular heartburn and acid-flux treatment in the UK. The main ingredient is Bismuth subsalicylate, and it is used to treat acid reflux, indigestion, nausea, heartburn, and diarrhoea
  • Gaviscon Double Action Tablets: Gaviscon is one of the leading treatments for acid reflux in the UK. It is a safe and effective antacid that provides fast-acting relief from symptoms of acid reflux and heartburn
  • Alka-Seltzer: These are effervescent tablets that contain the active ingredient Asprin. They offer fast and effective relief from mild pain, heartburn, and indigestion
  • Rennie Defaltine: Rennie is a popular brand name and is a non-prescription simethicone-based treatment that works to provide effective relief of bloating, trapped wind, heartburn and indigestion

Informational Sources

If you would like to know more about Esomeprazole tablets or about acid reflux and heartburn, we have compiled a list of additional resources for you to read:

Esomeprazole Reviews

Esomeprazole reviews are mixed. Half of users were happy with the medication and found that it provided effective relief from their heartburn and acid reflux. Those who left negative reviews noted that they experienced persistent and unpleasant side effects.


Learn moreicon-arrow-right

Esomeprazole Dosage & Directions of Use

Esomeprazole Dosage Options

  • Esomeprazole is available in two doses: 20mg and 40mg 
  • To start, the recommended dose is 40mg and is then reduced to 20mg

Usage Instructions for Esomeprazole 

  • Esomeprazole is not suitable for children less than 12 years old 
  • You can take Esomeprazole at any time during the day 
  • Esomeprazole can be taken on an empty stomach or after a meal 
  • Swallow Esomeprazole whole with a drink of water. It is important not to chew or crush the tablet as you will break the coating intended to protect the medicine from being broken down by your stomach acid

Always take Esomeprazole exactly as your doctor has prescribed. 

Learn moreicon-arrow-right

Esomeprazole Ingredients

Ingredients in Esomeprazole Tablets:

Active Substance: Esomeprazole

  • 20mg tablet: 20mg Esomeprazole
  • 40mg tablet: 40mg Esomeprazole

Other Ingredients:

  • Tablet core: Sugar spheres (maize starch, sucrose), sodium hydroxide, crospovidone, hydroxypropyl
  • Sub-coating: Sucrose, mannitol
  • Lubricant: Talc
  • Enteric coating: Triethyl citrate, methacrylic acid- ethyl acrylate polymer (1:1) dispersion 30%, polysorbate 80, glycerol monostearate

Side Effects
Learn moreicon-arrow-right

Esomeprazole Side Effects

As with all medications, side effects may occur, although not everyone will experience them.

Below, we discuss common side effects and uncommon side effects of Esomeprazole. If you are unsure if you are experiencing side effects from the medication or symptoms of your acid reflux, talk to your doctor or pharmacist.

Common Side Effects of Esomeprazole

Common side effects may affect up to 1 in 10 people; these include:

  • Headache
  • Nausea and vomiting
  • Diarrhoea
  • Stomach pain
  • Constipation
  • Flatulence (wind)
  • Benign polyps in the stomach

If you get persistent common side effects, talk to your doctor or pharmacist about other medication options.

Less common side effects of Esomeprazole

Less common or uncommon side effects may affect up to 1 in 100 people; these include:

  • Insomnia (disturbed sleep)
  • Swelling of the ankles and feet
  • Vertigo (spinning feeling)
  • Skin rash, hives, or itchy skin
  • Changes in blood tests (liver function)
  • Dry mouth
  • Dizziness, feeling sleepy, and pins and needles

If you experience an allergic reaction or severe side effects, seek medical attention immediately or call 999. The patient information leaflet provides more information about all reported or unreported side effects.

Learn moreicon-arrow-right

Esomeprazole Warnings

Before taking Esomeprazole, talk to your doctor or pharmacists:

  • If you have severe liver or kidney problems
  • If you are scheduled to have a specific blood test (Chromogranin A)
  • If you have ever had a skin rash after a treatment with medication that is similar to Esomeprazole

Esomeprazole may reduce the absorption of Vitamin B12. Esomeprazole may also hide the symptoms of other conditions; tell your doctor or pharmacist if you:

  • Have a problem swallowing or losing a large amount of weight for no reason
  • Get indigestion or stomach pain
  • Begin to vomit food or blood
  • Pass black stools (blood-stained)

Esomeprazole Drug Interactions

Talk to your doctor or pharmacist if you are taking any of the following medications:

  • Anti-fungal medications (ketoconazole, voriconazole, or itraconazole)
  • HIV medication (Atazanavir)
  • Cancer medication (Erlotinib)
  • St John’s wort
  • Rifampicin
  • Digoxin
  • Methotrexate
  • Tacrolimus
  • Diazepam
  • Citalopram, clomipramine, or imipramine (anti-depressants)
  • Phenytoin
  • Cisapride (for indigestion and heartburn)
  • Antibiotics (amoxicillin and clarithromycin)

Tell your doctor or pharmacist about any other herbal remedies, supplements, or vitamins that you may be taking.

Esomeprazole FAQs
Learn moreicon-arrow-right

What is Esomeprazole?

Esomeprazole is a medication used to reduce the amount of acid your stomach produces. It can be used to treat many conditions such as stomach ulcers and acid reflux. It belongs to a family of medicines called Proton Pump Inhibitors (PPIs). These act on the proton pumps in the stomach to reduce the amount of stomach acid produced.

Is Esomeprazole better than Omeprazole?

Both medicines are very similar and used to treat similar conditions. They generally work as well as each other but this can vary between patients. For some people, one might be more effective than the other. If you think Esomeprazole isn’t effective for you, discuss with your doctor about switching to a different PPI such as Omeprazole.

What is the best time to take Esomeprazole?

Usually, when you take one dose of Esomeprazole a day, you are advised to take it in the morning. However, you can take it at any time of the day and it should still be effective. Always take it as your doctor has told you to.

If you have been prescribed Esomeprazole twice a day, you should take one dose in the morning and one dose in the evening.

What is esomeprazole used to treat?

Esomeprazole is used to treat conditions that are caused by too much acid in the stomach. It is also used to treat Zollinger-Ellison syndrome, a condition where the stomach produces too much acid. 

Can you buy Esomeprazole over the counter in the UK?

Esomeprazole is available to buy over the counter under the brand name Nexium Control. This is available in packs of 7 or 14 tablets in 20 mg strength. Large pack sizes or higher strengths of Esomeprazole in the UK require a prescription.

You can request to order prescription-strength Esomeprazole using our online prescribing service. Our prescriber will review your medical assessment and prescribe it if safe and suitable to do so. Our pharmacy will then deliver the medicines to your chosen address via DPD or Royal Mail (please see delivery info here)

Is esomeprazole good for stomach gas?

No. Stomach gas may be a side effect caused by Esomeprazole. 

What are the expected side effects of esomeprazole?

The most common side effects of Esomeprazole include headache, nausea, gas (fluctuance), diarrhoea, and constipation. 

How long does it take for esomeprazole to work?

Esomeprazole generally takes 2-3 days to begin working; in some cases, it may take up to 4 weeks for this medication to work fully. 

Can I eat right after taking esomeprazole?

You can eat normally when taking Esomeprazole; it is advised to avoid eating or drinking anything that would normally cause your stomach discomfort. 

What should I avoid when taking Esomeprazole?

When taking Esomeprazole, you should avoid foods that make your indigestion worse, such as acid, spicy, fatty, or rich foods.

What causes acid reflux?

Certain drinks and food cause acid reflux and heartburn. Other causes include being overweight or obese, eating a large meal then lying down, and snacking close to bedtime.

Who Cannot take Esomeprazole?

Those who are using other medications containing rilpivirine, or certain antibiotics, have liver or kidney problems, or if you have ever had an allergic reaction to any other medication. 

Related Guides

Delve into a variety of content written by our medical experts

Esomeprazole Reviews

Confirm Esomeprazole treatment selection

20mg 28 Capsules £17.99
20mg 56 Capsules £23.99
20mg 28 Capsules £19.99
40mg 56 Capsules £24.99
20mg 14 Tablets £14.99
20mg 28 Tablets £17.99
20mg 56 Tablets £23.99
40mg 14 Tablets £15.99
40mg 28 Tablets £19.99
40mg 56 Tablets £24.99