Nevolat (Liraglutide)

It is important to read the Patient Information Leaflet (PIL) before taking any medicines. These can be found in the packaging or by searching at medicines.org.uk.

• Saxenda Patient Information Leaflet

Nevolat dosing

Most people who take Nevolat have one dose a day. At first, you will take a lower dose and gradually increase. The dosing schedule below should be followed for safe use.

How many doses in Nevolat pen?

One Nevolat pen holds 3ml (18mg) of Liraglutide. If you’re wondering how long one Nevolat pen lasts for, it varies. When you start your treatment, you will have around 17 days worth of doses in one pen.

When your dosage increases as advised by the dosing schedule, you will use a pen more quickly - many people start taking 3mg of Nevolat after a while. At this point, you will use a pen in 6 days.

How to take Nevolat

Nevolat comes in a 3ml pre-filled injection pen. The pen contains a clear and colourless or almost colourless solution.

All pens need needles for injecting. You will need to store your Nevolat pre-filled pen in a refrigerator (2°C to 8°C) before your first use. Once you start using the pen, you can keep it for 1 month either at room temperature (2 to 30°C) or in a refrigerator (2°C to 8°C). Do not freeze.

When you take Nevolat you need to gradually increase your dose in 0.6mg intervals, until you reach what is called the maintenance dose at 3mg daily. This is the dose at which you will continue to take Nevolat. You increase your dose as follows:

• Week 1 – 0.6mg as a once-daily injection
• Week 2 – 1.2mg as a once-daily injection
• Week 3 – 1.8mg as a once-daily injection
• Week 4 – 2.4mg as a once-daily injection
• Week 5 onwards – maintenance dose of 3.0mg as a once-daily injection

Increasing the dose slowly over time should minimise any unwanted side effects, such as nausea, vomiting and diarrhoea. As you increase your dose, if you find that you cannot tolerate your side effects, you should stay on the same dose for 2 continuous weeks.

If after 2 weeks your side effects are still not tolerable, you should consider stopping treatment.

The maximum recommended daily dosage of liraglutide is 3.0mg. Try to take it at the same time each day, picking a time that works for you, with or without food or drink.

You must continue with your new diet and exercise regime while you are taking Nevolat.

Always use Nevolat exactly how your prescriber has told you. Check with your doctor, pharmacist, or nurse if you are unsure.

When you first start Nevolat, a single pen will last 17 days and the first full pack of five pens will last six weeks. Once you have achieved the maintenance dose, a pack of five pens will last 30 days.

Please watch the video on how to administer Nevolat for more information.

Where do I inject Nevolat?

Please read the patient information leaflet here before using and watch the video.

• Nevolat is administered once daily.
• Inject your dose of Nevolat under the skin (subcutaneous injection) in your stomach area (abdomen), upper leg (thigh), or upper arm. It is also recommended that you alternate the site at which the injection is made.

Do not inject into a vein or muscle.

• Pinch the skin and push the needle all the way into the skin at a 90º angle
• Let go of the pinched skin. Inject the Nevolat and leave the syringe in place while you count slowly to 6 to make sure the full dose is delivered
• If the disposable needle found at the tip of one of your Nevolat pens bends out of shape whilst you are trying to use the pen, you should discard the needle and use a new one
• Never share your Nevolat pen or needles with another person. You may give an infection to them, or get an infection from them

How to store Nevolat

Store Nevolat in a refrigerator before using it for the first time. After your initial use, you can store the medication either at room temperature or in your refrigerator. Keep it protected from heat and sunlight.

Needle disposal (Needle Bin)

Every time you use Nevolat, you must use a needle. After each dose, the needle CANNOT be reused and must be disposed of appropriately using the sharps bin that is provided with the treatment.

If your sharps bin is full, you must dispose of it appropriately. Each county across the UK works differently, some areas allow you to dispose of needles at your local surgery, some at your pharmacy and others require you to contact your local council for a collection.

Further information can be found on the NHS website on "How Should I Dispose of Used Needles or Sharps"

Every council website will have information about how to dispose of your sharps bin, you can find your local council website by visiting the Find Your Local Council page on the UK government website.

If you are struggling to find somewhere in your local area to dispose of your sharps bin, please send us an email to help@cloudpharmacy.co.uk with the subject line "Local Sharps Bin Disposal" including your name address, contact telephone number and order number, and a member of our team will get in touch to tell you where to go in your area.

Under no circumstances (unless your locality has instructed you to do so) should your full sharps bin be disposed of with the rest of your household waste or in public/private bins.

Nevolat side effects

As with most medications, there are a few side effects that you should consider when taking Saxenda. Most of these potential side effects are mild with many people who take Saxenda not experiencing any side effects at all.

Common and mild side effects of Nevolat

• Nausea (probably the most common), which should weaken as you continue the course of Saxenda
• Vomiting
• Diarrhoea
• Flatulence
• Heartburn
• Constipation

If you experience diarrhoea or vomiting persistently, you may become dehydrated. Make sure that you are drinking as many fluids as possible to combat this. Contact your doctor if you experience dehydration symptoms that are not relieved by water. Dehydration symptoms include dry mouth, unusual thirst, lightheadedness, and headaches.

Serious side effects to Saxenda

• Change in the colour or amount of urine (this can indicate kidney problems)
• Fast or irregular heartbeats
• Unusual and dramatic changes in your mood
• Yellow eyes or skin (this can indicate liver issues)
• Sweating, blurred vision, tingling, shaking, or dizziness - these are signs of low blood sugar

If you experience these, seek medical attention immediately. Go to A&E or call 999 if you experience persistent nausea or vomiting and severe stomach pain. These symptoms indicate pancreatitis or gallbladder disease.

You are unlikely to have an allergic reaction while taking Saxenda. However, it’s important to be aware of the symptoms of an allergic reaction. If you experience itching or swelling around the face, difficulty breathing, severe dizziness or an unexplained rash, seek medical help immediately.

Precautions when taking Saxenda

Saxenda contains liraglutide. Do not take Saxenda if you have a known allergy to liraglutide. If you are allergic to any other medication, make sure that your doctor knows, as there may be inactive ingredients in Saxenda that make it unsuitable for your consumption.

If you have or have experienced the following conditions, make sure that you consult a doctor before trying Saxenda:

• Pancreatitis
• Depression or other mental disorders
• Gastroparesis or other stomach or intestinal disorders
• Kidney disease
• Liver conditions
• Diabetes - your doctor may still advise that you take Saxenda, but you will need to regularly check your blood sugar and consult your doctor. You also shouldn’t take Saxenda with some diabetic medicine

Do not use this medication if you are pregnant or if you suspect that you may be pregnant. It is also generally not advised to be taken while breastfeeding, as studies about whether it passes into breast milk are inconclusive.

Saxenda drug reactions

If you take any other medication, including prescription drugs, over-the-counter drugs, or herbal remedies, consult your doctor. Certain drugs react with Saxenda, and your doctor will have the most up-to-date information on which drugs to avoid.

Diabetes medications, including insulin, glyburide, exenatide, and dulaglutide, are known to interact with Saxenda. Consult your doctor if you take any of these medications or anything else for diabetes.